Enteric-coated tablets must not be what?

• A. Crushed or mixed with foods
• B. Stored in a cool, dry place
• C. Taken with water
• D. Split into halves

Answer: (A)

Enteric-coated tablets are designed to pass through the stomach intact and dissolve in the small intestine. Crushing them or mixing them with foods damages that protective coating, causing the drug to release early in the stomach. This can irritate the stomach lining, alter absorption, and reduce effectiveness. So they must not be crushed or mixed with foods. Swallow them whole with water and store them as directed. Splitting the tablet would also risk breaking the coating, but the primary reason is to keep the coating intact to ensure proper release.